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Ivars KALVINSH


Ivars KALVINSH

Head of Scientific Council,
Head of the Department of Medicinal Chemistry
Latvian Institute of Organic Synthesis

Aizkraukles iela 21,
Riga, LV-1006
Latvia

Phone: +371 67014800
Fax:       +371 6755 0338
E-mail: kalvins@osi.lv

Born: June 2, 1947, Riga, Latvia






Interests in inventing:

  • new physiologically active substances for CNS, cardiovascular and malignant diseases
  • chemistry of heterocyclic compounds and amino acid analogues
  • action of new medicines: biochemical mechanisms
  • immunochemistry

Main invention:

  • antiischaemic drug Mildronate
  • anticancer immunostimulator Leakadine
  • anti-inflammatory compound OX-MPI
  • anticancer drug Belinostat
  • neuroprotectant Neramexane

Selection of patent documents:

  • 260 inventions
  • 900 patents' documents (patents, applications, USSR authors' certificates)

Authors’ certificates of USSR:

  • 1,1,1-Trimethyl-2-(2- carboxylatoethyl)hydrazinium cviterion and method for the preparation. Co-authors: S.Hillers, A.Jeremejevs, V.Semenihina, E.Liepins. Nr. 529155
  • 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate and method for the preparation thereof. Co-authors: J.Lemba, I.Kramzaka, V.Aizbalts a.o. Nr. 1262900
  • Immunostimulator «Leakadine» for the treatment of oncological deseases. Co-author J. Astapjonoka. Nr. 1431118
  • Coronar active antiischaemic drug. Co-authors: A.Vinogradovs, M.Veveris, G.Arutjunovs, I.Makarova, D.Dmitrijevs, B.Simhovics, E.Lukevics, I.Zuravlova, A.Birmans, J.Halevs. Nr. 1464319

Patents of Latvia:

  • 1,1,1-Trimethyl-2(2- carboxylatoethyl)hydrazinium cviterion and method for the preparation. Co-authors: S.Hillers, A.Jeremejevs, V.Semenihina, E.Liepins. Pat. LV 5224
  • 3-(2,2,2-Trimethylhydrazinium)propionate dihydrate and method for the preparation. Co-authors: J.Lemba, I.Kramzaka, V.Aizbalts, J.Melbergs, A.Sidorovs, A.Zarins. Pat. LV 5046
  • Immunostimulator «Leakadine» for the treatment of oncological deseases. Co-authors J.Astapjonoka. Pat. LV 5182
  • Coronar active antiischaemic drug. Co-authors: A.Vinogradovs, M.Veveris, G.Arutjunovs, I.Makarova, D.Dmitrijevs, B.Simhovics, E.Lukevics, I.Zuravlova, A.Birmans, J.Halevs. Pat. LV 5397

Patents of USA:

  • Eremeev A., Kalvinsh I., Semenikhina V., Liepinsh E.E., Latvietis Y.Y., Anderson P.P., Astapenok E.B., Spruzh Y.Y., Trapentsiers P.T., Podoprigora G.I., Giller S.A. 3-(2,2,2-Trimethylhydrazinium)propionate and method for the preparation and use thereof. Pat. 4481218 US.
  • Kalvinsh I.Y., Vinogradov A.V., Veveris M.M., Makarova I.I., Birman A.S., Barmotin G.V., Akifiev O.N. Treatment of cardio-vascular diseases with 3-(2,2,2-trimethylhydrazinium)propionate dihydrate. Pat. 4451485 US.
  • Kalvinsh I.Y., Astapenok E.B. Pharmaceutical composition and method for treating tumors susceptible to 2-carbamoylaziridine. Pat. 4686215 US

About the inventions

  • Leakadine reacts with albumen of cancer cell membranes, making them easier to eliminate by means of immunoprotection system
  • Mildronate is based on the mechanism of original action mechanism unifying elimination of fat flow through cell membranes, prevention of activated fat accumulation, recovery of ATP transportation, acceleration of glucose oxidation, optimization of oxygen consumption in cells, recovery of sarcoplasmic reticulum Ca+2-ATPhase and activation of NO biosynthesis – all together ensuring the protection of myocardial muscle against overload.

Implementation:

Sold licences:

  • company “Iskra” - mildronate
  • company “Grindex” - mildronate
  • company “Grindex” – neomildronate

Awards:

Honours and Awards

  • Corresponding Member, Latvian Academy of Sciences, 1994
  • Full Member, Latvian Academy of Sciences, 1994
  • Member of European Academy of Sciences and Arts, 2012
  • Honorary Academician, Ukrainian Medical Stomatological Academy, 2006
  • Latvian SSR State Prize for Science and Technology,  1988
  • D.H. Grindel Medal for merits in the synthesis and investigations of drugs (company " Grindex", Latvia), 1996
  • S.Hillers Medal for contribution to the development of medicinal preparations (Latvian Institute of Organic Synthesis), 1997
  • Oswald Schmiedeberg Medal (Tartu University, Tartu, Estonia), 2001
  • Gustav Vanags' Prize of  Latvian Academy of Sciences for series of publications "Synthesis and investigation of bioactive low-molecular NO-inductors and donors", 2003
  • Paul Walden's Medal for outstanding contribution to the development of medicinal chemistry in Latvia and series of works devoted to the development of a new approach in the creation of medicaments", 2003
  • St.George Medal awarded by International rating Academy "Golden Fortune" in collaboration with the ortodox church of the Ukraine for the succesful co-operation between Latvia and Ukraine, 2004
  • The Solomons Hillers Prize  for outstanding achievements in biomedicine and the design of new medications (a cycle of investigations "Synthesis, development and introduction into practice of a cycloprotector with an original mechanism of action Mildronate) , 2005 
  • Certificate and Golden Medal  of World Intellectual Property Organisation (WIPO) for long-term and highly productive work as inventor, 2005
  • The Three Stars Order of the Republic of Latvia, 2006
  • The Award of the Cabinet of Ministers, Republic of Latvia, 2006
  • The Grand Medal of the Latvian Academy of Sciences for creation of new competitive medicinal preparations and strenghthening of innovative orientation in the Latvian Institute of Organic Synthesis, 2009
  • Honorary Diploma of the Cabinet of Ministers of the Republic of Latvia, 2014
  • Cicero award of the Latvian Academy of Sciences and University of Latvia for outstanding contribution to preparation of globally recognized medication, 2014
  • Finalist for the European Inventor Award, 2015
  • The Walter Zapp Prize, established by the Latvian Academy of Sciences, Patent Office of the Republic of Latvia and company Minox (Germany) to honour outstanding inventors, 2015

Work in poffessional community:

Professional Activities and Memberships

  • President, Latvian Chemical Society, 1994 - 2000
  • Member of Council, Latvian Agency of Medicines, 1994 - 2002
  • Member of Senate, Latvian Academy of Sciences, since 1994
  • Editor-in-Chief, journal "Chemistry of Heterocyclic Compounds", since 2010
  • Member, Editorial Board for Latvian Journal of Chemistry, since 1996
  • Member, Editorial Board for Proceedings of the Estonian Academy of Sciences, since 1998
  • Member, Editorial Board for Molecules, since 2003
  • Head of Library Council, Latvian Academy of Sciences,  1998 - 2010
  • Head of Promotion Council in Pharmacy, Riga Stradins University, since 2007
  • Head of Board, Latvian Innovators Union, since 2009
  • Chairman of Board of the Latvian Fund Taiho, since 2009
  • Head of Association of Latvian State Research Institutes, since 2009
  • Head of Council, Union of Latvian Scientists, since 2009
  • Chairman of Board,  Association «Baltic Institute of Research, Technology and Innovation» (BIRTI), 2013
  • Member of Advisory Convent, Riga Stradins University, since 2008
  • Chairman of Advisory Convent, Liepaja University, 2013

More about the inventor (in Latvian)

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